CAREERS AT MICROVASCULAR THERAPEUTICS
Lead Scientist
Main Responsibilities
Development and characterization of innovative formulations (lyophilized, pulverized product) of targeted and/or untargeted microbubbles and nano-emulsions.
Development and full characterization of nanodroplets from nano-emulsions.
Develop and perform stability studies of experimental batches.
Specific Responsibilities
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Conduct Research and Development processes and controls established by company Quality Management System
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Research and develop formulations
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Develop in vitro assays for the characterization of the formulations
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Propose, design, execute and analyze experiments individually and as a team with collaborators, colleagues, and supervisor
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Perform laboratory work including chemical characterization of chemical intermediates and products formulation
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Maintain detailed and organized laboratory notebook with detailed observations
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Peer review laboratory notebooks
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Analyze, document, and interpret data
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Prepare and deliver scientific writings and presentations
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Assist with the preparation of grant proposals, applications, and closeout reports
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Participate in patent preparation
Requirements
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PhD in Pharmaceutical sciences and pharmaceutics combined with a minimum 1-3 years industrial research experience in medical devices and/or pharmaceuticals
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Knowledge in detection and treatment of cancer, cardiovascular and neurological disorders and experience and skills in organic, biological and analytical chemistry
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Excellent working knowledge and direct experience in a breadth of analytical tools, materials testing, prototyping/equipment
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Validated practical experience in design, experimentation, statistics, and data analysis
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Excellent problem solving capability
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Excellent written and verbal communication skills
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Perform the following routine laboratory duties:
- Ensure laboratory areas are clean and organized
- Troubleshoot and perform routine repairs and maintenance of laboratory equipment as needed
- Monitor the status of laboratory supplies
- Maintain weekly schedules and report any changes to the CSO/COO
Manufacturing/Formulation Scientist
Main Responsibilities
Develop injectable products based on lipid-based perfluorocarbon micro/nanoemulsions for clinical and commercial use, including product process development and scale-up, product characterization, technology transfer, and GMP manufacturing,
Adhere to cGMP or current good manufacturing practices, standard operating methods and legal regulations to maintain a safe and clean work environment.
Document all production efforts in appropriate logs, forms, reports and databases.
Specific Responsibilities
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Lead, design and execute in-process development studies for product manufacturing
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Develop strategy and product process development and scale up studies for manufacturing of lipid-based perfluorocarbon formulations.
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Support characterization and manufacturing
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Develop experimental and supervise plans and execute studies to assess physicochemical stability
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Work independently with counterparts from other functional areas to deliver on CMC milestones while adhering to broad project timelines
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Generate, document and compile data for team and senior management discussions,
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Resolve manufacturing issues, while being mindful of supply chain, quality, and regulatory consideration
Requirements
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PhD in Biochemistry, Pharmaceutical Sciences, or Engineering combined with a minimum 1-5 years industrial research experience in medical devices and/or pharmaceuticals OR MS with 5-10 years experience
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Excellent working knowledge and direct experience in a breadth of analytical tools, materials testing, prototyping/equipment, in vitro assays and in vivo models
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Validated practical experience in design, experimentation, statistics, and data analysis
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Excellent problem solving capability
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Excellent written and verbal communication skills
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Working knowledge of quality systems and regulatory compliance pertaining to FDA/EU approval
Physical Demands
. Ability to bend or stand as necessary. Ability to carry, lift and/or displace larger items/boxes.
This job description does not include or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.
CONTACTS: Emmanuelle Meuillet at e.meuillet@mvtpharma.com to send your CV or if you have any questions. regarding the positions.